A single-center observational study of the relationship between sleep synovial fluid cytokine profiles & outcomes of ACL reconstruction

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Acute Acl Tear
  • Age: Between 18 years - 100 years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Male or female,at least 18 years of age who provide written informed consent
    2. Undergoing primary ACL reconstruction with BPTB autograft for acute ACL tear, with or without concomitant meniscectomy
    3. Showing symptoms within 2 weeks of injury and undergoing reconstruction within 8 weeks of injury

You may not be eligible for this study if the following are true:

    1. Breastfeeding or pregnant
    2. History of blood-borne diseases including HIV, HBV, HCV, HTLV, or syphilis
    3. Multiligamentous knee injury
    4. Concomitant meniscal repair, meniscal allograft transplantation, osteotomy, or repair of focal chondral defect
    5. Prior ipsilateral knee surgeries or injuries
    6. Primary sleep disorders including insomnia, sleep apnea, or restless legs syndrome
    7. Uncontrolled psychiatric disorders with sleep disturbance
    8. Night shift work
    9. Travel with time zone change within three weeks of surgery
    10. Systemic inflammatory disease
    11. Autoimmune disease
    12. Immunomodulatory drug use
    13. Chemotherapy within a year before surgery
    14. Intra-articular injection within 3 months before surgery



If you are registered as a volunteer, please log in to contact the study team/express interest in this study.