Long-acting buprenorphine vs. naltrexone opioid treatments in CJS-involved adults

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Opioid Use Disorder
  • Age: Between 18 - 65 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Adult volunteer able to provide written informed consent in English
    2. Current CJS incarceration (residing in a controlled environment) with pending release date (within 6 months of randomization) OR community CJS-involvement defined as:
      • Current CJS incarceration (residing in a controlled environment) with pending release date (within 6 months of anticipated randomization)
      • ommunity-dwelling volunteers with current CJS-involvement. Current CJS-involvement is defined as either 1) release from any CJS incarceration or detention, or 2) under community supervision
    3. Current or history of moderate-to-severe opioid use disorder
    4. Not planning to move out of state or to new location within 6-months post-release
    5. Willing to accept either XR-B or XR-NTX assignment

You may not be eligible for this study if the following are true:

    1. Medical or psychiatric disorders
    2. Pregnant, planning conception or breast-feeding
    3. Allergy, hypersensitivity or medical contraindication to either medication
    4. Chronic pain requiring opioid pain management
    5. On daily stable methadone or buprenorphine (SL-B) maintenance every day for past 30 days prior to incarceration or monthly XR-NTX or XR-BUP 30 days or longer prior to incarceration AND intending to remain on same form of methadone or buprenorphine or XR-NTX maintenance upon return to the community



If you are registered as a volunteer, please log in to contact the study team/express interest in this study.