Metformin in Alzheimer's Dementia Prevention (MAP)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Amnestic Mild Cognitve Impairment
  • Age: Between 55 years - 90 years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    Amnestic mild cognitive impairment(aMCI) subjects:
    1. Must have subjective memory concern reported by subject, study partner, or clinician.
    2. A mini-mental state exam = 24 for subjects with more than 8 years of education. For subjects with less than 8 years of education, a MMSE = 20 will be allowed.
    3. Clinical Dementia Rating =0.5. The memory box score must be at least 0.5
    4. Abnormal memory function documented by scoring within the education adjusted ranges on the Logical Memory II subscale (Delayed Paragraph Recall, Paragraph A only) from the Wechsler Memory Scale-Revised.
    5. Subjects without a known history of diabetes
    6. Overweight or obese by National Heart, Lung, and Blood Institute (NHLBI) criteria (BMI = 25 kg/m2)
    7. Vision and hearing must be sufficient for compliance with testing procedures
    8. Must have a study partner to come to all appointments or be available by telephone at follow-up visits
    Study Partner:
    1. The study partner can provide an independent evaluation of functioning for a person enrolled in the MAP study as a participant
    2. The study partner agrees to attend study visits with the MAP participant or be available by telephone

You may not be eligible for this study if the following are true:

    1. Use of metformin for any indication
    2. Subjects with eGFR < 45 ml/min
    3. Those with liver disease other than non-fatty liver disease (e.g. Cirrhosis) or class II of IV congestive heart failure
    4. History of intolerance to metformin used for indications other than diabetes
    5. History of cerebrovascular accident with residual neurological deficits
    6. Moderate to severe depression
    7. Dementia diagnosis
    8. Lack of capacity to consent
    9. Neurologic diseases associated with neurologic deficits
    10. Current Axis I psychiatric diagnoses such as major depression, bipolar disorder or schizophrenia
    11. Alcohol or substance abuse or dependence in the past 6 months
    12. Use of medications rated as being the likely cause of cognitive impairment
    13. Normal individuals without cognitive complaints
    14. Uncontrolled hypertension (systolic blood pressure = 160 mmHg or diastolic blood pressure = 95 mmHg)
    15. history of active cancer or cancer within last five years
    16. planning to move to another city or state within the next 24 months.
    17. known history of diabetes
    18. Subjects who for any reason may not complete the study as judged by the study physician
    19. Use of cholinesterase inhibitors
    20. Not able to undergo phlebotomy
    21. Pregnant

If you are registered as a volunteer, please log in to contact the study team/express interest in this study.