Metformin in Alzheimer's Dementia Prevention (MAP)
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Amnestic Mild Cognitve Impairment
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Age: Between 55 years - 90 years
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Gender: Male or Female
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Other Inclusion Criteria:
Amnestic mild cognitive impairment(aMCI) subjects:- Must have subjective memory concern reported by subject, study partner, or clinician.
- A mini-mental state exam = 24 for subjects with more than 8 years of education. For subjects with less than 8 years of education, a MMSE = 20 will be allowed.
- Clinical Dementia Rating =0.5. The memory box score must be at least 0.5
- Abnormal memory function documented by scoring within the education adjusted ranges on the Logical Memory II subscale (Delayed Paragraph Recall, Paragraph A only) from the Wechsler Memory Scale-Revised.
- Subjects without a known history of diabetes
- Overweight or obese by National Heart, Lung, and Blood Institute (NHLBI) criteria (BMI = 25 kg/m2)
- Vision and hearing must be sufficient for compliance with testing procedures
- Must have a study partner to come to all appointments or be available by telephone at follow-up visits
- The study partner can provide an independent evaluation of functioning for a person enrolled in the MAP study as a participant
- The study partner agrees to attend study visits with the MAP participant or be available by telephone
You may not be eligible for this study if the following are true:
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- Use of metformin for any indication
- Subjects with eGFR < 45 ml/min
- Those with liver disease other than non-fatty liver disease (e.g. Cirrhosis) or class II of IV congestive heart failure
- History of intolerance to metformin used for indications other than diabetes
- History of cerebrovascular accident with residual neurological deficits
- Moderate to severe depression
- Dementia diagnosis
- Lack of capacity to consent
- Neurologic diseases associated with neurologic deficits
- Current Axis I psychiatric diagnoses such as major depression, bipolar disorder or schizophrenia
- Alcohol or substance abuse or dependence in the past 6 months
- Use of medications rated as being the likely cause of cognitive impairment
- Normal individuals without cognitive complaints
- Uncontrolled hypertension (systolic blood pressure = 160 mmHg or diastolic blood pressure = 95 mmHg)
- history of active cancer or cancer within last five years
- planning to move to another city or state within the next 24 months.
- known history of diabetes
- Subjects who for any reason may not complete the study as judged by the study physician
- Use of cholinesterase inhibitors
- Not able to undergo phlebotomy
- Pregnant
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.