Global Prevalence of Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in Participants with Heart Failure with Preserved Ejection Fraction (HFpEF)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Heart Failure With Preserved Ejection Fraction
    Transthyretin Amyloid Cardiomyopathy (attr-cm)
  • Age: Between 60 - 150 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Participants must provide written informed consent
    2. Medical history of heart failure (HF) with
      • At least 1 episode with clinical evidence of HF (without hospitalization) by signs or symptoms of volume overload or elevated intracardiac pressures that required/requires treatment with a diuretic for improvement; OR
      • 1 prior hospitalization for HF
    3. Willing and able to undergo scintigraphy
    4. Participants who are willing and able to comply with all scheduled visits, laboratory tests, and other study procedures

You may not be eligible for this study if the following are true:

    1. Diagnosis of heart failure with reduced ejection fraction (HFrEF) (EF =40%)
    2. Prior clinical history of myocardial infarction, CABG or multi-vessel obstructive coronary disease
    3. Presence or history of any severe valvular heart disease
    4. A confirmed diagnosis of a non-amyloid infiltrative cardiomyopathy, muscular dystrophies, cardiomyopathy with reversible causes, hypertrophic obstructive cardiomyopathy with known genetic etiology, or known pericardial constriction
    5. Any type of diagnosed amyloidosis or prior diagnosis of ATTR-CM
    6. Other medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator’s judgment, make the participant inappropriate for the study



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