Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)

Brief description of study

People with mild cognitive impairment (MCI) have more memory problems than normal for people their age, but their symptoms are not as severe as those of people with Alzheimer’s disease. They are able to carry out their normal daily activities and make important medical decisions. Some, but not all, people with MCI go on to develop Alzheimer’s disease. The primary purpose of this research study is to determine if application of near infrared energy to the forehead can help improve thinking and memory in people with MCI. Near infrared energy is like light but is not visible to the human eye. This study will compare near infrared exposure with a placebo or sham procedure. The sham procedure will look and feel just like the near infrared procedure but won’t include near infrared exposure. A sham procedure is used in research studies to compare the results and side effects of the treatment being studied to the results and side effects of receiving no treatment.


Clinical Study Identifier: s20-00865
ClinicalTrials.gov Identifier: NCT04784416
Principal Investigator: Dan Iosifescu.
Other Investigators: Martin Sadowski, Nunzio Pomara, David Liebers, Simon Khuvis, Antonio J Convit, Ricardo Miguel Osorio Suarez, Kathy F Yates, Naomi L Gaggi, Thomas M Wisniewski, Ryan Brown, Thaddeus Tarpey.


If you are registered as a volunteer, please log in to contact the study team/express interest in this study.

Contact the research team to learn more about this study.

By clicking "Contact Research Team", your contact information will be sent securely to the research staff associated with the study. You will also receive a copy of this email in your inbox, as well as other notifications to determine your participation status in the study.