Phase 3 trial of oral ALZ-801 in Early AD patients who are homozygous for the epsilon 4 variant of the Apolipoprotein E gene (APOE4/4)

Brief description of study

The purpose of this study is to determine if the study drug called ALZ-801 is safe, if it is well tolerated (how your body reacts to the study drug) and if it is effective in treating Alzheimer’s Disease (AD). ALZ-801 has an active agent called tramiprosate, which interferes with the formation of abnormal forms of a protein called beta amyloid or Aß-42. These abnormal amyloid proteins are thought to play an important role in causing cell damage in the brain and the development of AD. ALZ-801 inhibits the formation of these abnormal toxic proteins and may be able to slow down or stop the worsening of AD. To determine if ALZ-801 is effective, a comparison must be made between ALZ-801 and placebo. A placebo looks like the study drug but does not contain any active drug. Researchers use a placebo to see if a study drug works better or is safer than not taking anything at all.

Clinical Study Identifier: s20-01820 Identifier: NCT04770220
Principal Investigator: Thomas M Wisniewski.
Other Investigator: Arjun V. Masurkar.

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