Understanding CSF Clearance in Aging and Alzheimer s Brain Through Dynamic Sodium MRI

Brief description of study

The purpose of this study is to see whether or not there is a relationship between cerebrospinal fluid (CSF) clearance in human brain with normal aging, with sleep, and with Alzheimer's disease (AD). Recent studies of mice showed that impairment of the CSF clearance pathway led to a 70% reduction in A-beta clearance, while sleep-induced enhancement of CSF flow increased A-beta clearance by 100%. It is unclear whether or not these impairment and enhancement effects exist in humans and how they change with aging. The clearance of A-beta proteins is critically important to prevent or delay AD progression.

Clinical Study Identifier: s20-01231
Principal Investigator: Yongxian Qian.

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