Understanding CSF Clearance in Aging and Alzheimer s Brain Through Dynamic Sodium MRI
Brief description of study
The purpose of this study is to see whether or not there is a relationship between cerebrospinal fluid (CSF) clearance in human brain with normal aging, with sleep, and with Alzheimer's disease (AD). Recent studies of mice showed that impairment of the CSF clearance pathway led to a 70% reduction in A-beta clearance, while sleep-induced enhancement of CSF flow increased A-beta clearance by 100%. It is unclear whether or not these impairment and enhancement effects exist in humans and how they change with aging. The clearance of A-beta proteins is critically important to prevent or delay AD progression.
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.