Controlled Study Comparing the Immune Response and Safety of a Research Yellow Fever Vaccine Candidate to a Licensed Yellow Fever Vaccine for Adults

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Yellow Fever
  • Age: Between 18 - 60 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. You are able to attend all scheduled visits and comply with all study procedures
    2. For female participants: You are not pregnant or breastfeeding and meet one of the following criteria:
      • Are not of childbearing potential (you must be at least 1 year postmenopausal or be surgically unable to have children) or
      • Are of childbearing potential and agree to use an effective contraceptive method at least 4 weeks before and 4 weeks after study vaccination and have a negative pregnancy test before receiving the study vaccine

You may not be eligible for this study if the following are true:

    1. You are taking part in another study for a vaccine, drug, medical device, or medical procedure, 4 weeks before study enrollment or plan to take part in another study during the first 2 years of the study follow up period
    2. You received any other vaccine 4 weeks before the study vaccination or plan to receive any other vaccine 4 weeks after study vaccination. (Exception: You may receive a flu vaccine at least 2 weeks before study vaccination)
    3. You previously received any kind of vaccine against FV disease including a vaccine against yellow fever
    4. You received any antibodies (immunoglobulins) or any blood or blood-derived products in the past 6 months
    5. You have a weakened immune system or received any medications that can weaken your immune system (ex: any anti-cancer treatment or radiation therapy in the last 6 months or systemic corticosteroid treatment such as prednisone for more than 2 consecutive weeks in the past 3 months)
    6. You previously had an FV infection
    7. You have a known allergic reaction to any part of a vaccine including eggs or a known history of a life-threatening reaction to a vaccine ingredient used in the study
    8. You are living with HIV
    9. You have a history of hepatitis B or hepatitis C
    10. You have a personal or family history of any thymic conditions (ex: thymoma, thymectomy, or myasthenia)
    11. You are deprived of freedom by any administrative or court order, or in an emergency setting, or hospitalized involuntarily
    12. You abuse alcohol, prescription drugs, or substances in a way that, in the opinion of the Investigator, might interfere with the study’s conduct or completion
    13. You have a chronic illness including a malignancy such as leukemia or lymphoma that in the opinion of the Investigator is at a stage where it might interfere with the study’s conduct or completion
    14. You have a moderate or severe acute illness or a fever of 100.4 degrees F or greater on the day of vaccination
    15. You are an employee directly involved in the conduct of the study or are an immediate family member (i.e. parent, spouse, natural or adopted child) of an employee with direct involvement in the study
    16. You plan to travel to a country at high risk for yellow fever within 6 months of study vaccination



If you are registered as a volunteer, please log in to contact the study team/express interest in this study.