Clinical Research Studies

This will be a quantitative, prospective study. Patients with small bowel Crohn’s will be enrolled in the study. Patients will undergo an initial DECTE prior to starting a new therapy as is already performed by standard of care. Following implementation of medical therapy, patients will undergo a follow-up DECTE 4 to 8 months later as is performed by standard of care. Medical therapies are at the discretion of the gastroenterologist caring for the patient as per standard of care. The iodine density will be determined and 3D iodine density maps will be created for each patient at the time of both DECTE examinations. We will be required to record patient name, MRN, accession number of each CT, patient age, gender, and clinical data including the Crohn’s disease activity index (CDAI), which is a calculated score based on a combination of clinical and laboratory values that do not involve PHI. PHI (MRN, accession number, name, dates of scans) will be used to identify patients for inclusion in the study and for comparison with follow-up imaging. All PHI will be removed at the earliest opportunity. The age, gender and initial clinical information will be recorded while first identifying patients. Clinical information will also be recorded at the time of follow-up CT. Following the 2nd DECTE, all PHI including MRN and accession number will be discarded. Each patient will be assigned a random identification number for anonymous image review. No link to PHI will be maintained.