CAreful Ventilation In ARDS The CAVIARDS Trial

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CAreful Ventilation In ARDS The CAVIARDS Trial

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

Conditions:
Covid-19
Age: Between 18 Year(s) - 100 Year(s)
Gender: Male or Female

Other Inclusion Criteria:
1. Moderate or severe ARDS within 48 h of meeting Berlin ARDS criteria
  - Within 1 week of a known clinical insult or new or worsening respiratory symptoms
  - Bilateral opacities—not fully explained by effusions, lobar/lung collapse, or nodules
  - Respiratory failure not fully explained by cardiac failure or fluid overload. Need objective assessment (eg, echocardiography) to exclude hydrostatic edema if no risk factor present
  - PaO2/FIO2 = 200 mm Hg with PEEP = 5 cmH2O

You may not be eligible for this study if the following are true:

1. Received continuous mechanical ventilation >7 days
2. Known or clinically suspected elevated intracranial pressure (>18 mmHg) necessitating strict control of PaCO2
3. Known pregnancy
4. Broncho-pleural fistula
5. Severe liver disease (Child-Pugh Score =10)
6. BMI>40 kg/m2
7. Anticipating withdrawal of life support and/or shift to palliation as the goal of care
8. Already receiving ECMO at time of randomization

Contact the research team to learn more about this study.

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