A Single-Center Observational Study to Develop EEG Biomarkers of Transition from Acute to Chronic Pain

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Pain, Not Elsewhere Classified
  • Age: Between 18 - 75 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Participants with diagnosis of acute low back pain by a clinician, with predominant low back pain, with or without leg pain (acute pain arm only) OR diagnosis of chronic low back pain by a clinician, with predominant low back pain, with or without leg pain, and pain lasting greater than 6 months (chronic pain arm only)
    2. Pain-free control participants who have no pain
    3. For participants with acute or chronic pain, baseline average pain intensity > 4 on a 0-10 numerical rating scale in the back
    4. American Society of Anesthesiologists (ASA) physical status 1, 2, or 3
    5. Medically stable
    6. Willing and able to participate in study procedures

You may not be eligible for this study if the following are true:

    1. Pain lasting greater than 6 weeks at the time of recruitment [acute pain arm only]
    2. Acute lumbosacral radiculopathy with neurological signs such as sensory loss, motor weakness, and decreased reflexes
    3. Low back pain with any systemic signs or symptoms
    4. Cognitive impairment (by history) or clinical signs of altered mental status
    5. A diagnosis of schizophrenia and/ or a history of chronic antipsychotic medication use
    6. Current benzodiazepine use
    7. Unwillingness to give informed consent
    8. Exclusions for MRI, including claustrophobia, metallic implants, medication patches
    9. Pregnancy



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