Mesoscopic Biomarkers of Neurodegeneration and Inflammation with Diffusion MRI

Brief description of study

In this study, novel diffusion MRI markers in brain white matter will be evaluated to yield clinically feasible non-invasive MR markers that are sensitive and specific to diffuse neurodegenerative and inflammatory processes in brain white matter of Multiple Sclerosis patients. The white matter microstructure markers will be evaluated in their ability to track disease progression, both in a cross-sectional and longitudinal design in MS patients with a varying range of disability. Ultimately, the MRI pipeline for estimating WM microstructure markers will be straightforwardly extendable beyond MS, to help understand and quantify neurodegeneration and inflammation in other neurological diseases.

Clinical Study Identifier: s19-01000

Principal Investigator: Els Diane Tonia Fieremans.

Other Investigators: Ilya Kister, Dmitry Novikov, Lauren B. Krupp, Kimberly Ann O'Neill, Timothy Michael Shepherd.

Contact the research team to learn more about this study.

Your Email

Not a valid e-mail address

Please Provide Email Address

First Name

First name is mandatory

Last Name

Your Phone

Please provide phone number

Invalid phone number

Valid phone number

Comments

Send Confirmation of This To Me

By clicking "Contact Research Team", your contact information will be sent securely to the research staff associated with the study. You will also receive a copy of this email in your inbox, as well as other notifications to determine your participation status in the study.

Clinical Research Studies