Preventing Arthritis in a Multi-Center Psoriasis At-Risk Cohort (Multi-Center PAMPA Study)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
  • Age: Between 18 Year(s) - 60 Year(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Psoriasis diagnosis (per dermatologist) for at least 2 years
    2. Willing and able to provide informed consent
    3. Fulfillment of high-risk psoriasis (HR-PsO) criteria (Psoriasis (PsO) patients will meet the definition of High-risk(HR) if they fulfill the following criteria:a) PsO duration >2 years and Psoriasis Body Surface Area (BSA) >3% and positive imaging findings in MSKPDUS defined as a RM-PsASon score of >3.36

You may not be eligible for this study if the following are true:

    1. Evidence of inflammatory joint pain, enthesitis and/or dactylitis on exam
    2. Current systemic immunosuppressive medication use (i.e., methotrexate, apremilast) at the time of enrollment or biologic therapy (ever)
    3. RA seropositivity (mid-high RF/ACPA titers)
    4. Current active malignancy
    5. History of symptomatic polyarticular OA or other joint conditions (such as RA, gout, etc) that may impair the ability to assess for PsA development
    6. Conditions where initiation of guselkumab is prohibited in the prescribing information, including clinically important active infection and untreated latent tuberculosis
    7. Known hypersensitivity to the study agent

If you are registered as a volunteer, please log in to contact the study team/express interest in this study.

Contact the research team to learn more about this study.

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