Preventing Arthritis in a Multi-Center Psoriasis At-Risk Cohort (Multi-Center PAMPA Study)
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Psoriasis
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Age: Between 18 Year(s) - 60 Year(s)
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Gender: Male or Female
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Other Inclusion Criteria:
- Psoriasis diagnosis (per dermatologist) for at least 2 years
- Willing and able to provide informed consent
- Fulfillment of high-risk psoriasis (HR-PsO) criteria (Psoriasis (PsO) patients will meet the definition of High-risk(HR) if they fulfill the following criteria:a) PsO duration >2 years and Psoriasis Body Surface Area (BSA) >3% and positive imaging findings in MSKPDUS defined as a RM-PsASon score of >3.36
You may not be eligible for this study if the following are true:
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- Evidence of inflammatory joint pain, enthesitis and/or dactylitis on exam
- Current systemic immunosuppressive medication use (i.e., methotrexate, apremilast) at the time of enrollment or biologic therapy (ever)
- RA seropositivity (mid-high RF/ACPA titers)
- Current active malignancy
- History of symptomatic polyarticular OA or other joint conditions (such as RA, gout, etc) that may impair the ability to assess for PsA development
- Conditions where initiation of guselkumab is prohibited in the prescribing information, including clinically important active infection and untreated latent tuberculosis
- Known hypersensitivity to the study agent
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.