A One Year Observational Investigation of Subjects with Open Angle Glaucoma And a Documented History of Progressive Visual Field Loss

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Open Angle Glaucoma
  • Age: Between 18 - 99 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Perimetric early and moderate, open angle glaucoma
    2. At least 4 prior consecutive reliable visual fields for potentially eligible eye(s) within the last 60 months with evidence of visual field progression (slope of -0.5 to -1.0 dB/year) and confirmed by the Visual Field Reading Center
    3. Visual acuity is greater than or equal to 20/40 (Snellen)
    4. Ability to accurately perform perimetry reliably as determined by the Visual Field Reading Center with less than 15% false positives
    5. Ability to continue with medical therapy
    6. Ability to have transportation to/from testing center

You may not be eligible for this study if the following are true:

    1. Humphrey MD score better than -2.0 dB or worse than -12.0 dB
    2. Zeiss RNFL OCT at or near floor (average RNFL thickness <60 microns) in the past 24 months
    3. IOP < 15 mmHg or IOP greater than 28 mmHg
    4. Media opacities (e.g. corneal scars, posterior subcapsular cataracts, etc.) that might account for field defect or prevent reliable perimetry
    5. Prior intraocular glaucoma surgery within 24 months of baseline visit
    6. Prior laser trabeculoplasty (SLT, ALT) within 6 months of baseline visit
    7. Diabetic retinopathy (proliferative or non-proliferative)
    8. Non-glaucomatous optic neuropathy
    9. Systemic, psychiatric, neurological disease, or any other condition which would preclude finishing the study at prescribed time intervals
    10. Any CNS disease that could either limit ability to perform perimetry or mask glaucomatous damage



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