Women s Ischemia Trial to Reduce Events in Non-Obstructive CAD

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Coronary Artery Disease
  • Age: Between 18 years - 100 years
  • Gender: Female
  • Other Inclusion Criteria:
    1. Signs and symptoms of suspected ischemia prompting referral for further evaluation by cardiac catheterization, or coronary angiogram or coronary CT angiogram within 5 years from consent
    2. Non-obstructive CAD defined as 0 to 49% diameter narrowing of a major epicardial coronary artery
    3. Willing to provide written informed consent

You may not be eligible for this study if the following are true:

    1. History of noncompliance to medical therapy or follow-up
    2. History of non-ischemic dilated or hypertrophic cardiomyopathy
    3. Documented acute coronary syndrome within previous 30 days
    4. Left ventricular ejection fraction (LVEF) less than 40%, NYHA class III-IV, or hospitalization for heart failure with reduced ejection fraction (HFrEF) within 180 days
    5. Stroke within previous 180 days or intracranial hemorrhage at any time
    6. End-stage renal disease, on dialysis, or estimated glomerular filtration rate (eGFR) less than 30 ml/min.
    7. Severe valvular disease or likely to require surgery/TVAR within 3 yrs
    8. Life expectancy less than 3 years due to non-cardiovascular comorbidity
    9. Enrolled in a competing clinical trial.
    10. Prior intolerance to both an ACE-I and ARB
    11. If intolerant to a statin unless taking a PCSK9 as a statin replacement by their clinical provider
    12. Pregnant

If you are registered as a volunteer, please log in to contact the study team/express interest in this study.