A pilot proof of concept study of the Effects of Administration of SCFA in Rheumatoid Arthritis (EASi-RA)

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A pilot proof of concept study of the Effects of Administration of SCFA in Rheumatoid Arthritis (EASi-RA)

Brief description of study

The purpose of this research is to study the effects of administering an oral short chain fatty acid (SCFA) dietary supplement along with methotrexate as first line treatment in new onset rheumatoid arthritis (RA) patients. Short chain fatty acids (SCFAs) are gut bacterial fermentation byproducts that are naturally found at varying concentrations in the gut and have been shown to increase host regulatory immune responses and induce changes in the gut microbiota in various animal models of inflammatory disease. SCFAs are not an FDA approved treatment for RA or for any other condition but are sold over the counter as nutritional supplements.

Clinical Study Identifier: s20-02068

ClinicalTrials.gov Identifier: NCT05152615

Principal Investigator: Jose U Scher.

Other Investigators: Sergei B Koralov, Rebecca Barbara Blank.

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