Early Detection Of Alpha-Synuclein Disease
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Synucleinopathies
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Age: Between 18 years - 90 years
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Gender: Male or Female
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Other Inclusion Criteria:
- Possible prodromal synucleinopathy
- Diagnosis of Parkinson´s disease (PD), Lewy Body Dementia (DLB), Multiple System Atrophy (MSA)
- Adult (age = 18) men and women who are ambulatory and functionally independent and able to provide appropriate consent as determined by screening study physician
- Willingness to participate in study procedures (skin biopsy)
You may not be eligible for this study if the following are true:
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- Existing diagnosis or evidence of advanced neurodegenerative disorder
- Unstable psychiatric illness, including psychosis, suicidal ideation, or untreated major depression within 90 days before Initial Visit, as determined by investigator
- History or baseline MRI results showing evidence of structural abnormalities that could contribute to the participant’s clinical state, or any finding that might pose a risk to the participant
- Major coexisting disability or medical condition that would prevent accurate assessment or prevent safe participation in study tasks, including peripheral neuropathy secondary to diabetes mellitus, amyloidosis, paraneoplasic syndrome, neurotoxin-induced or other causes
- History of any brain surgery for movement disorders (e.g., pallidotomy, deep brain stimulation, or fetal tissue transplant) or a history of focused ultrasound treatment or neuromodulation procedures.
- Participants with abnormal coagulation results (PT/INR, aPTT)
- History of human immunodeficiency virus or hepatitis C virus antibody.
- Chronic, recurrent, or serious infection
- History of unstable angina, myocardial infarction, chronic heart failure (New York Heart Association Class 3 or 4), or clinically significant conduction abnormalities
- History of, or ongoing, malignant disease
- History of any clinically significant endocrinological, hematologic, hepatic, immunologic, metabolic, urologic, pulmonary, neurologic, dermatologic, renal, ischemic, or other major diseases
- Clinically significant allergies
- Participation in a clinical trial testing potential investigational disease-modifying drug
- Unwillingness or inability to comply with the requirements of this protocol.
- Other unspecified reasons that, in the clinical opinion of the Investigator, make the participant unsuitable for enrollment
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.