Elucidating Neural Mechanisms and Sex Differences in Response to Mindfulness Based Stress Reduction in Generalized Anxiety Disorder

Brief description of study

The purpose of this research study is to understand to how Mindfulness-Based Stress Reduction (MBSR)compared to a Stress Education (SE) class works for patients with generalized anxiety disorder (GAD). Specifically we want to understand brain changes (“neural mechanisms”) that contribute to reduction in GAD symptoms with MBSR treatment compared to Stress Education (SE), and to examine the degree to which treatment response may be explained by sex differences in these neural mechanisms. GAD is a mental health disorder with specific core features, such as worry and anxiety about the future that lasts for at least 6 months.


Clinical Study Identifier: s21-00454
ClinicalTrials.gov Identifier: NCT05064813
Principal Investigator: Naomi M. Simon.


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