Elucidating Neural Mechanisms and Sex Differences in Response to Mindfulness Based Stress Reduction in Generalized Anxiety Disorder

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Generalized Anxiety Disorder
  • Age: Between 18 - 50 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
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  • A primary mental health complaint of Generalized Anxiety Disorder (GAD)
  • Overall clinical anxiety severity of at least mild as defined by a CGI-S of at least 3
  • Individuals who are able and willing to participate in the informed consent process and comply with the requirements of the study protocol.
  • Able to provide proof of COVID-19 vaccination at in person screen visit

You may not be eligible for this study if the following are true:

    1. A lifetime history of bipolar disorder, schizophrenia, psychosis, or delusional disorders; obsessive-compulsive disorder or an eating disorder in the past 12 months; neurocognitive disorders, intellectual disabilities, communication disorders or other cognitive dysfunction that could interfere with capacity to engage in therapy or complete study procedures
    2. Substance or alcohol use disorder (other than nicotine) in the last 6 months or otherwise unable to commit to refraining from alcohol use during the acute period of study participation
    3. Individuals with significant suicidal ideation (assessed by CSSRS SI score greater than 2) or who have enacted suicidal behaviors within 6 months prior to intake
    4. Individuals unstable medical illness, or a condition for which hospitalization may be likely within the next year as assessed by medical history and physical exam.
    5. Pregnant women and women of childbearing potential who are not using medically accepted forms of contraception
    6. Any concurrent psychotherapy initiated within 3 months of baseline, or ongoing psychotherapy of any duration directed specifically toward treatment of GAD
    7. Individuals who have completed a course of MBSR or an equivalent meditation training or who have an ongoing regular meditation practice in the past 2 years
    8. Individuals with a history of head trauma causing loss of consciousness, seizure or ongoing cognitive impairment
    9. Contraindications for MRI including metal implants, surgical clips, probability of metal fragments, or braces that are prohibited due to severe risk of injury
    10. Left handed individuals



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