Intra-Individual Variability in Cognitive Performance as a Marker of Prodromal Disability in MS

Brief description of study

The purpose of this research study is to develop a way of detecting the very early signs of cognitive decline in patients with Multiple Sclerosis (MS). The researchers will analyze cognitive performance (thinking abilities) as well as brain activity using magnetic resonance imaging (MRI) and transcranial direct current stimulation (tDCS). MRI is a routine medical procedure that takes pictures of the body, in this case, the brain. tDCS is a non-invasive brain stimulation that applies low electrical current to the brain. The researchers are using tDCS to help with obtaining images of brain activity and it is not intended as treatment.

Clinical Study Identifier: s21-01385

ClinicalTrials.gov Identifier: NCT05543915

Principal Investigator: Leigh E. Charvet.

Other Investigators: Lauren B. Krupp, Yulin Ge.

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