Intra-Individual Variability in Cognitive Performance as a Marker of Prodromal Disability in MS

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Multiple Sclerosis
  • Age: Between 23 - 59 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Prodromal MS (defined by radiologically isolated syndrome = 6 months from first MRI or clinically isolated syndrome = 3 months from first clinical event)

You may not be eligible for this study if the following are true:

    1. Below average estimated premorbid cognitive functioning (based on WRAT-4 reading recognition standard z-score < 85)
    2. Presence of severe cognitive impairment (based on SDMT age normative z-score <-3.0)
    3. Currently using disease modifying therapies (DMT)
    4. Primary psychiatric disorder that would influence ability to participate
    5. Current uncontrolled seizure disorder
    6. Current substance abuse disorder
    7. History of head trauma in the past year (e.g., head injury, brain surgery) or medical device implanted in the head (such as Deep Brain Stimulator) or in the neck (such as a Vagus Nerve Stimulator)
    8. Pregnant or breastfeeding
    Participants having the MRI with tDCS:
    1. Extreme claustrophobia
    2. Any skin disorder/sensitive skin (e.g., eczema, severe rashes), blisters, open wounds, burn including sunburns, cuts or irritation, or other skin defects which compromise the integrity of the skin at or near stimulation locations (where electrodes are placed)
    3. Treatment for a communicable skin disorder currently or over the past 12 months
    4. Have any irremovable piercings, metallic based-tattoos, or MRI-contraindicated implants (e.g. pacemakers and defibrillators)



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