Assessment of immunological and vascular dysfunction in neuropsychiatric post-acute sequelae of SARS-CoV-2 using TSPO PET and MRI

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Assessment of immunological and vascular dysfunction in neuropsychiatric post-acute sequelae of SARS-CoV-2 using TSPO PET and MRI

Brief description of study

The overarching goal of this study is to develop PET/MR techniques for the diagnosis of neuropsychiatric post-acute sequelae (PASC) of SARS-CoV-2. Our central hypothesis is that immunological and cerebrovascular dysfunction after acute SARS-CoV-2 infections mediate neuropsychiatric PASC (NP-PASC).

Clinical Study Identifier: s21-00945

ClinicalTrials.gov Identifier: NCT05615415

Principal Investigator: Steven H. Baete.

Other Investigators: William G. Frankle, Dan Iosifescu, Benjamin Brush, Eytan Raz, Yulin Ge, Jennifer A. Frontera, Claude Steriade, Jelle Veraart, Jean Logan, Binita Shah.

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