Assessment of immunological and vascular dysfunction in neuropsychiatric post-acute sequelae of SARS-CoV-2 using TSPO PET and MRI

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Coronavirus As The Cause Of Diseases Classified To Other Chapters
  • Age: Between 18 - 50 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    Volunteers with neuropsychiatric symptoms following COVID:
    1. Cognitive dysfunction and or
    2. Depression or anxiety symptoms
    Volunteers who have a history of COVID, but no long term symptoms:
    1. History of Infection with SARS-CoV-2
    2. Does not meet criteria for any DSM-5 diagnosis
    3. Perform within normal limits on cognitive tests
    All:
    1. At least 12th grade educational level
    2. Infection with SARS-CoV-2 (3-12 months ago)
    3. Able to sign informed consent as evaluated by the UCSD Brief Assessment of Capacity to Consent (UBACC) test.

You may not be eligible for this study if the following are true:

    1. Less than 3 months past the last SARS-CoV-2 vaccine administration
    2. Suicidal ideation
    3. Pregnant women
    4. Known history of serious our unstable medical illness associated with chronic inflammation other than PASC
    5. Obese individuals (BMI >= 30) and individuals with cardiovascular risk factors
    6. A history of chronic pre-existing neurological disease, i.e. neurological symptoms should be new onset for inclusion
    7. A history of any of the following pre-existing DSM-5 psychiatric illnesses (i.e. symptoms should be new onset for inclusion): schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorders not otherwise specified, bipolar disorder, patients with mood congruent or mood incongruent psychotic features, anxiety disorders (e.g. Panic d/o, GAD, PTSD) which are considered the primary mental health problem, OCD or OCD-spectrum disorders, neurocognitive disorders
    8. Clinical or laboratory evidence of hypothyroidism
    9. Recent traumatic brain injury
    10. Patients with substance use disorders, including alcohol, active within the last 12 months
    11. Current use of any psychotropic drugs, including current use of antidepressants, benzodiazepines, hypnotics, anticonvulsants, antipsychotics
    12. Patients who have had electroconvulsive therapy (ECT) within the preceding 6 months
    13. Contraindications to 3T whole body MRI scanners
    14. Contraindications for Gadolinium-based MRI contrast
    15. Claustrophobia
    16. Recent exposure to radiation which when combined with this study would be above the allowable limits of 5 rem per 12 months
    17. If CSF sampling: contraindication for a lumbar puncture
    18. Unable to sign informed consent or to comply with study assessments



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