Predicting poor vaccine responders to Hepatitis B vaccination

Brief description of study

The purpose of this study is to understand how the immune system learns from the hepatitis B vaccine and why some people do not respond to the vaccine. Approximately 5-50% (5-50 in 100) of people who need hepatitis B vaccine do not develop immunity despite getting three doses of the classic vaccine. The immune system “learns” from a vaccine through the actions and changes to T and B cells (types of cells in your immune system), but there are many details that we do not understand. Understanding how people respond to different versions of the hepatitis B vaccine will help researchers understand how to design better, more effective vaccines.

Clinical Study Identifier: s20-01782 Identifier: NCT04674462
Principal Investigator: Ramin Herati.
Other Investigator: Mark J. Mulligan.

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