Investigating the Temperature Dependence of Age-related Tau Pathology Relevant to Early Alzheimer's Disease

Brief description of study

The purpose of this study is to assess how day to day patterns in how your body temperature naturally varies over time may contribute to increasing risk for developing Alzheimer’s disease. The study will enroll 120 adults aged between 60–80 years. We will be testing to see whether specific patterns in body temperature, recorded over 2 days, are associated with results from several tests. These tests will include cognitive evaluations, a PET-MR scan, and a blood test. During the two days we measure your body temperature, we will ask you to visit the sleep lab at night to have your sleep assessed, because body temperature and sleep are closely related. We hope to identify the mechanisms by which age-related body temperature and sleep changes contribute to AD neurodegeneration in normal elderly patients, the group that could profit the most from sleep improvement strategies.

Clinical Study Identifier: s21-00833
Principal Investigator: Esther Blessing.

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