THE NEPHROTIC SYNDROME STUDY NETWORK (NEPTUNE)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Nephrotic Syndrome
  • Age: Between 1 - 105 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    Inclusion Criteria for the Focal and Segmental Glomerulosclerosis/Minimal Change Disease Cohort:
    1. A new diagnosis of Focal and Segmental Glomerulosclerosis FSGS or Minimal Change Disease (MCD)according to characteristic light, electron (EM), and immunofluorescence microscopy (IM), with presence of at least five glomeruli per biopsy available for analysis.
    2. Documented urinary protein excretion greater than or equal to 500 mg/24 hours or spot protein
    Inclusion criteria for the Membranous Nephropathy Cohort:
    1. A new diagnosis of Membranous Nephropathy (MN)according to characteristic light, electron (EM), and immunofluorescence microscopy (IM), with presence of diagnostic changes in at least one glomerulus per biopsy.
    2. Documented urinary protein excretion greater than or equal to 500 mg/24 hours or spot protein
    Inclusion criteria for the Other Glomerulopathies Cohort
    1. A new diagnosis of glomerulopathy according to characteristic light, electron (EM), and immunofluorescence microscopy (IM), with presence of diagnostic changes in at least one glomerulus per biopsy.
    2. Documented urinary protein excretion greater than or equal to 500 mg/24 hours or spot protein

You may not be eligible for this study if the following are true:

  • Exclusion criteria for the FSGS/MCD and MN Cohorts
    1. Prior solid organ transplant
    2. A clinical diagnosis of FSGS/MCD or MN without diagnostic renal biopsy
    3. Clinical, serological or histological evidence of systemic lupus erythematosus (SLE)
    4. Clinical or histological evidence of other renal diseases
    5. Known systemic disease diagnosis at time of enrollment with life expectancy less than 6 months
    6. Unwillingness or inability to give a comprehensive informed consent
    7. Unwillingness to comply with study procedures and visit schedule
    8. Institutionalized individuals (e.g., prisoners)
    9. Laboratory information unavailable prior to consent and biopsy procedure subsequently supporting exclusion criteria will deem a participant ineligible
    Exclusion Criteria for the Other Glomerulopathies
    1. Prior solid organ transplant
    2. A clinical diagnosis of glomerulopathy without diagnostic renal biopsy
    3. Clinical, serological or histological evidence of systemic lupus erythematosus (SLE)
    4. Clinical or histological evidence of other renal diseases
    5. Known systemic disease diagnosis at time of enrollment with life expectancy less than 6 months
    6. Unwillingness or inability to give a comprehensive informed consent
    7. Unwillingness to comply with study procedures and visit schedule
    8. Institutionalized individuals (e.g., prisoners)
    9. Laboratory information unavailable prior to consent and biopsy procedure subsequently supporting exclusion criteria will deem a participant ineligible



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