Study to Optimize Immune Coverage of SARS-CoV-2 Existing and Emerging Variants COVAIL Booster Study

Brief description of study

The purpose of this research is to test additional vaccine booster shots that use different vaccine types and/or variant spikes to see if these new combinations are safe and to evaluate the immune system responses. Vaccines tell your germ-fighting cells to make antibodies and other substances to fight infections. All the study vaccines are intended to train the immune system so that if the person is then infected with the SARS-CoV-2 virus, they have a “head start” and the infection can be stopped or made less severe. Using a booster vaccine that has one or more different variant spikes, or the original spike in combination with variant spikes, may improve protection against variant strains. You cannot get COVID-19 from the study vaccine. If you are interested in participating in the study, please email .

Clinical Study Identifier: s22-00332 Identifier: NCT05289037

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