Racial diffErences in the aSsociation Of sLow waVe slEep aNd Tau (RESOLVENT II)

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Racial diffErences in the aSsociation Of sLow waVe slEep aNd Tau (RESOLVENT II)

Brief description of study

This pilot proposal will examine whether racial differences exist in the association between SWS/SWA and in-vivo regional tau-PET signal for a given level of global Aß burden. To generate preliminary data for a larger R01 application, we will leverage data and resources from NYU Alzheimer’s Disease Research Center (ADRC NYULH STUDY ID#: s20-00427) and two affiliated ongoing NIH supported R01 studies (2R01AG056031 NYULH STUDY ID#: s17-01005 and 1R01AG056531 NYULH STUDY ID#: s18-01302). Altogether, subjects will include 100 cognitively normal (50 blacks from NYULH STUDY ID#: s18-01302 & 50 whites {35 from NYULH STUDY ID#: s17-01005 & 15 from NYULH STUDY ID#: s20-00427 ) without OSA (thereby eliminating a possible confounder of reduced SWS), ages 60-75, matched on age, sex, BMI, education and income.

Clinical Study Identifier: s21-00410

Principal Investigator: Omonigho Michael Bubu.

Other Investigators: Ricardo Miguel Osorio Suarez, Arjun V. Masurkar.

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