Racial diffErences in the aSsociation Of sLow waVe slEep aNd Tau (RESOLVENT II)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Alzheimer's Disease
  • Age: Between 60 - 75 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    Inclusion criteria for subjects who participated in s17-01005
    1. Control (non-OSA) subjects AHI4%<15 confirmed from medical record review of results from their sleep studies in s17-01005
    2. Male and female subjects with normal cognition and ages 60 to 75, confirmed from medical record review and results of their clinical evaluations in s17-01005
    3. Within normal limits on neurological and psychiatric examinations
    4. Self-identified as non-Hispanic white
    5. Subjects who have a Global Deterioration Scale of 3, with absence of memory impairment and a clinical consensus diagnosis of Mild Cognitive Impairment due to Vascular contributions are allowed
    6. Participating in NYULH STUDY ID#: s17-01005 with available OR will have full clinical evaluation data, neuroimaging measures of vascular burden, amyloid, and nocturnal polysomnography (NPSG) recordings
    Inclusion criteria for subjects who participated in s20-00427
    1. Male and female subjects with normal cognition and ages 60 to 75, confirmed from medical record review and results of their clinical evaluations in s20-00427
    2. Within normal limits on neurological and psychiatric examinations
    3. Self-identified as non-Hispanic white
    4. Subjects who have a Global Deterioration Scale of 3, with absence of memory impairment and a clinical consensus diagnosis of Mild Cognitive Impairment due to Vascular contributions are allowed.
    5. Participating in NYULH STUDY ID#: s20-00427, with available OR will have full clinical evaluation data, neuroimaging measures of vascular burden, amyloid, and tau-PET
    Inclusion criteria for subjects who participated in s18-01302
    1. Male and female subjects with normal cognition and ages 60 to 75, confirmed from medical record review and results of their clinical evaluations in s18-0132
    2. Within normal limits on neurological and psychiatric examinations
    3. Self-identified as African-American Black
    4. Subjects who have a Global Deterioration Scale of 3, with absence of memory impairment and a clinical consensus diagnosis of Mild Cognitive Impairment due to Vascular contributions are allowed.
    5. Participating in NYULH STUDY ID#: s18-01302 with available OR will have full clinical evaluation data, neuroimaging measures of vascular burden, amyloid, and nocturnal polysomnography (NPSG) recordings

You may not be eligible for this study if the following are true:

    1. Irregular sleep-wake rhythms (based on participant self-report), short sleepers (< 5 hours a day) and long sleepers (> 10 hours a day)
    2. Self-identified as US-born Caribbean Black, Caribbean-born Black or African-born Black
    3. Have varying levels of OSA (defined as AHI4%>15 and AHI4%>5 with Epworth >=10) from moderate to Severe
    4. Any subjects with cumulative radiation exceeding the limits of 50 mSv per year, which is set by the FDA for individuals participation in basic research studies will be excluded from the study



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