A Randomized Double-Blind Placebo-Controlled Study in Cat-Allergic Patients with Allergic Rhinitis Who Live with a Cat to Assess the Efficacy and Safety of Anti-Fel d 1 Antibodies during Natural Cat Exposure in the Home

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Allergic Rhinitis
  • Age: Between 12 - 100 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Weight must be equal to or greater than 40 kg at the time of screening
    2. Documented or patient reported history (for at least 2 years) of symptomatic cat allergen triggered allergic rhinitis with or without conjunctivitis and with or without asthma
    3. At least 1 generally healthy cat (that is unlikely to die during the study) living in the home resulting in regular exposure
    4. Willing and able to comply with clinic visits and study-related procedures
    5. Provide informed consent
    6. Able to understand and complete study-related questionnaires

You may not be eligible for this study if the following are true:

    1. History of significant multiple and/or severe allergies
    2. Received REGN1908-1909 in a prior REGN1908-1909 clinical trial
    3. Active lung disease other than asthma
    4. Treatment with an investigational drug within 2 months or within 5 half-lives
    5. Persistent chronic or recurring acute infection requiring treatment with antibiotics, antivirals, or antifungals, or any untreated respiratory infections within 4 weeks prior to screening.
    6. Use of anti-IgE or other biological therapy (including but not limited to anti IL-5, anti IL-4) that interferes with type 2 disease within 6 months prior to screening visit 1
    7. Specific immunotherapy (SIT) with cat allergen or cat vaccine within 6 months prior to screening visit 1
    8. SIT with any allergen other than cat within 6 months prior to screening visit 1
    9. Patients who have recently started (within 12 weeks prior to screening visit 1) and plan to continue or plan to start their cat(s) on an anti-allergen cat food (eg, Purina Pro Plan® LiveClear) or other anti-allergen treatment during the study
    10. History of life-threatening asthma
    11. History of intensive care hospitalization for asthma within past 2 years
    12. History of intolerance to systemic or topical corticosteroids or antihistamines, or drug treatment excipient
    13. History of nasal polyps
    14. History of drug or alcohol abuse within a year prior to screening
    15. Any malignancy within the past 5 years
    16. Pregnant or breastfeeding women
    17. Women of childbearing potential (WOCBP)* who are unwilling to practice highly effective contraception prior to the initial dose/start of the first treatment, during the study, and for at least 24 weeks after the last dose

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