Clinical Research Studies

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Drpla
• Age: Between 0 Year(s) - 99 Year(s)
• Gender: Male or Female

• Other Inclusion Criteria:
  

  Adult Study

  1. DRPLA adult participants must be 16 years old or over at the time of enrollment, to participate
  2. DRPLA adult participants must have a genetic diagnosis of DRPLA and CAG repeat expansion >35
  3. Patient is able to read, understand, and provide written informed consent (signed and dated. If the patient is under the age of 18 or is unable to provide consent, the patient must have a parent or caregiver capable of providing informed consent (signed and dated) and able to attend all scheduled study visits, and provide feedback regarding the participant's symptoms and performance as described in the protocol
  4. Adult pre-symptomatic subjects must have a positive genetic test for the DRPLA expansion without symptoms compatible with the disease, and be 16 years old or over at the time of enrollment.
  5. Adult Family/Community control participants must be 16 years old or over at the time of enrollment to participate. Blood-relatives must not have a genetic diagnosis of DRPLA or their genetic status is unknown.

  Pediatric Study

  1. DRPLA pediatric participants must be under 16 years old at the time of enrollment, to participate.
  2. DRPLA adult participants must have a genetic diagnosis of DRPLA and CAG repeat expansion >35
  3. If the patient is under the age of 18 or is unable to provide consent, the patient must have a parent or caregiver capable of providing informed consent (signed and dated) and able to attend all scheduled study visits, and provide feedback regarding the participant's symptoms and performance as described in the protocol
  4. Pediatric Family/Community control participants must be under 16 years old at the time of enrollment to participate. Blood-relatives must not have a genetic diagnosis of DRPLA or their genetic status is unknown.

  
  

You may not be eligible for this study if the following are true:

• Adult Study

  1. Individuals with an ataxia condition other than DRPLA.
  2. Failure to sign the consent form will result in study exclusion.
  3. Has any condition or circumstance that, in the opinion of the Investigator, makes the participant unsuitable for enrolment. These may include medical conditions which might affect the measurement of biomarkers.
  4. Participants will be excluded from the lumbar puncture, and skin biopsy procedures if they have a history of severe allergic or anaphylactic reactions or other adverse reactions to local anesthetics used in the study.
  5. For family/community controls: those individuals with neurological conditions (other than primary headache disorders) will be excluded.

  Pediatric Study

  1. Individuals with an ataxia condition other than DRPLA.
  2. Failure to sign the consent form will result in study exclusion.
  3. Has any condition or circumstance that, in the opinion of the Investigator, makes the participant unsuitable for enrolment. These may include medical conditions which might affect the measurement of biomarkers.
  4. Participants will be excluded from the skin biopsy procedures if they have a history of severe allergic or anaphylactic reactions or other adverse reactions to local anesthetics used in the study.
  5. For family/community controls: those individuals with neurological conditions (other than primary headache disorders) will be excluded.