Microbial and host biomarkers for endotyping critically ill patients

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Microbial and host biomarkers for endotyping critically ill patients

Brief description of study

We will prospectively collect airway, stool and blood samples on 1000 subjects admitted to the ICU with diagnosis of sepsis, acute respiratory distress symdrome (ARDS) or pneumonia. We will evaluate airway/gut microbial signatures associated with local (lower airway) and systemic (blood) immune tone. We will then study whether airway/gut microbial signatures are associated with clinical outcomes (Aim 1) and dysbiotic signatures are associated with host immune endotypes (Aim 2).

Clinical Study Identifier: s22-00616

Principal Investigator: Leopoldo N. Segal.

Other Investigators: Carlos Leon Alviar, Radu Postelnicu, Benjamin G Wu, Clea Rose Barnett, Anna Nolan, Shari Barnett Brosnahan, Sripal Bangalore, Jun-Chieh J. Tsay, Anthony S Lubinsky, David A. Kaufman, Vikramjit Mukherjee, Benjamin Kwok, Kerry Hena.

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