Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

Brief description of study

The purpose of this research study is to see if a medication called clozapine helps to reduce violence in people with schizophrenia. The study will assign participants by chance (like flipping a coin) to receive either clozapine or a different antipsychotic drug assigned by their doctor. The study will last about 24 weeks and involves around 26 visits. While in this study, you will be asked to come in for weekly visits, take antipsychotic medication, and participate in blood draws, questionnaires, urine samples, and medical monitoring. At each appointment we will also ask to speak with an individual you identify as being familiar with your behavior in the community since the last assessment. Study staff will reach out to this informant and collect information about violence, suicidality, and symptoms as needed.

Clinical Study Identifier: s20-02054 Identifier: NCT05208190
Principal Investigator: Donald C Goff.

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