Post-Cardiopulmonary Bypass Vasoplegia: Cytokine/Chemokine/Immunotranscriptomic Causes or Consequences

Brief description of study

All patients undergoing open heart surgery with the utilization of cardiopulmonary bypass (CPB) are at risk for developing varying degrees of vasoplegia. Although a precise definition is lacking, vasoplegia is a physiologic state characterized by hypotension (systolic blood pressure <90mmHg) with low systemic vascular resistance (SVR) <800 dynes, and adequate cardiac index. Patients demonstrating vasoplegia after CPB require escalating doses of vasoactive medications to maintain an adequate blood pressure, significantly increasing their risk for progressive organ failure and death. The common use of CPB for open heart surgery and the connection between CPB-induced endothelial damage and the development of vasoplegia will be examined.

Clinical Study Identifier: s22-00001

Principal Investigator: Deane E Smith.

Other Investigators: Chandra Mouli Goparaju, Kenneth Tokoro, Nader Moazami, Harvey I Pass, Eugene A Grossi, Aubrey C Galloway, Leslie James, Elias A Zias, Sallie M Yassin.

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