A Phase 2a Multicenter Randomized Doubleblind Study Evaluating the Efficacy and Safety of Subcutaneously Administered combination therapy in Improving the Signs and Symptoms in Participants with Active Psoriatic Arthritis.

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A Phase 2a Multicenter Randomized Doubleblind Study Evaluating the Efficacy and Safety of Subcutaneously Administered combination therapy in Improving the Signs and Symptoms in Participants with Active Psoriatic Arthritis.

Brief description of study

This is a Phase 2a randomized, double-blind, active-controlled, parallel-group, multicenter, proof-of-concept (POC) clinical study designed to evaluate the efficacy and safety of combination therapy with guselkumab+golimumab (guselkumab 100 mg q4w + golimumab 50 mg q4w) versus guselkumab monotherapy (guselkumab 100 mg q4w + placebo) in adults with active PsA who have a previous history of IR to one anti-TNFa therapy either due to primary nonresponse or loss of efficacy.

Clinical Study Identifier: s21-00936

ClinicalTrials.gov Identifier: NCT05071664

Principal Investigator: Jose U Scher.

Other Investigators: Soumya M Reddy, Fardina Malik, Michael Toprover, Rebecca Haberman, Rebecca Barbara Blank.

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