Brain Fog Following COVID-19 (SARS-COV-2 Infection)

Brief description of study

The purpose of this study is to examine whether or not individuals who were previously diagnosed with SARS-CoV-2, or COVID-19, have greater cognitive and biomarker changes over five years than those individuals who did not have COVID-19.

This is a prospective, observational, longitudinal cohort study (n=300) of the following groups:

  1. SARS-CoV-2 laboratory positive subjects who have new objective or subjective cognitive abnormalities within 12 months of SARS-CoV-2 infection (COVID+Cog+);
  2. SARS-CoV-2 laboratory positive subjects without new cognitive findings within 12 months of SARS-CoV-2 infection (COVID+Cog-); or
  3. SARS-CoV-2 negative subjects who are cognitively normal (Controls).
Participants will have demographic and medical history collected, along with cognitive testing, blood testing, gait measurements, olfactory testing and a brain MRI. Participants will be tested every 12 months over the course of 5 years, and undergo a total of three brain MRIs. Each visit will last approximately 6 hours (interviews and cognitive testing) and each MRI is approximately 45 minutes.

Participants will be compensated $50 for travel expenses and an additional $75 for each completed MRI.

We are currently recruiting people who have never had a history of COVID-19 and who have never tested positive for SARS-CoV-2 or COVID-19.


Clinical Study Identifier: s22-00517
Principal Investigator: Thomas M Wisniewski.
Other Investigators: Arjun V. Masurkar, Sujata P. Thawani, Yulin Ge, Allal Boutajangout, Jennifer A. Frontera, Laura J Balcer.


If you are registered as a volunteer, please log in to contact the study team/express interest in this study.

Contact the research team to learn more about this study.

By clicking "Contact Research Team", your contact information will be sent securely to the research staff associated with the study. You will also receive a copy of this email in your inbox, as well as other notifications to determine your participation status in the study.