Transcatheter Pulmonary Valve Replacement and Catheter Ablation of Ventricular Tachycardia in Tetralogy of Fallot

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Transcatheter Pulmonary Valve Replacement and Catheter Ablation of Ventricular Tachycardia in Tetralogy of Fallot

Brief description of study

Patients with TOF that are referred for transcatheter PVR may harbor undiagnosed substrates for sustained monomorphic or polymorphic VT irrespective of their baseline SCD risk. We hypothesize that the combination of VT circuit elimination and favorable reverse remodeling following PVR may operate synergistically to reduce the risk for sustained MVT and SCD for patients with TOF, avoiding the need for alternative therapies. The present study aims to evaluate risk reduction for patients with TOF undergoing transcatheter PVR by performing electrophysiological studies with catheter ablation of demonstrated potential VT substrates prior to transcatheter PVR.

Clinical Study Identifier: s22-00412

Principal Investigator: Reina Tan.

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