Single-center observational longitudinal study to identify predictors of progression of joint damage after non-contact rupture of anterior cruciate ligament

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Single-center observational longitudinal study to identify predictors of progression of joint damage after non-contact rupture of anterior cruciate ligament

Brief description of study

Post-traumatic osteoarthritis (PTOA) is a common occurrence after anterior cruciate ligament (ACL) rupture independently of patient treatment, which indicates that early cellular and molecular changes directly after injury seem to be critical in disease development. The goal of this study is to develop a predictive model of progression to PTOA using a combination of multinuclear magnetic resonance imaging markers, soluble synovial fluid biological markers, and biomechanical markers acquired on patients just after ACL injury, and at different time points after joint repair. This prognostic combination of biomarkers will help identify therapeutic targets and monitor the efficacy of intervention in the development of preventive treatments of PTOA.

Clinical Study Identifier: s22-00560

Principal Investigator: Guillaume N Madelin.

Other Investigators: Gregory Chang, Eric J Strauss, Thorsten Kirsch, Smita Rao, Maria Amparo Ruiz Garzon.

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