Clinical Research Studies

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Acl Rupture
• Age: Between 18 Year(s) - 45 Year(s)
• Gender: Male or Female

• Other Inclusion Criteria:
  

  ACL Patient Participants:
  1. BMI: 18 to 35 kg/m2.
  2. Non-contact ACL injury within last 4 weeks previous to the doctor’s visit, and positive ACL laxity on physical examination (positive pivot shift and/or positive Lachman test) or confirmed ACL rupture by imaging or surgery.

  Healthy Volunteers:
  1. BMI: 18 to 35 kg/m2.

  
  

You may not be eligible for this study if the following are true:

• ACL Patient Participants:
  1. Standard contraindications to MRI: implanted metal devices beyond the surgical pins from ACL reconstruction, pacemaker, metal implants, renal impairment, cerebral aneurysm clip, cochlear implant, presence of shrapnel in strategic locations, metal in the eye, claustrophobia, presence of electronic devices or ferromagnetic metallic foreign or implanted object that could constitute a hazard during MRI or any other contraindications to MRI.
  2. Individuals with history of knee trauma previous to the ACL injury or any other form of arthritis (including rheumatoid arthritis, spondyloarthritis, active crystal arthropathy).
  3. Individuals with history of any disorder requiring the use of systemic corticosteroids within one week of screening.
  4. Individuals with history of hyaluronan and/or corticosteroid injections to the affected knee within 3 months of the inclusion.
  5. Pregnant women.
  6. Individuals with past or present neurological disorder.
  7. Individuals with alcohol or drug dependency.
  8. Individuals unable to sign informed consent or to comply with study assessments (cognitive impairment, etc.).

  Healthy Volunteers:
  1. Standard contraindications to MRI, as described above.
  2. Individuals with history of any other form of arthritis (including rheumatoid arthritis, spondyloarthritis, active crystal arthropathy).
  3. Pregnant women.
  4. Individuals with alcohol or drug dependency.
  5. Individuals unable to sign informed consent or to comply with study assessments (cognitive impairment, etc.).