Phase 1 Clinical Trial of Innate Immunity Stimulation via TLR9 in Early AD (Part the Cloud)

Brief description of study

The purpose of this study is to evaluate the safety, tolerability, and effectiveness of study drug called CpG 1018 ISS to slow or prevent Alzheimer’s disease (AD) progression. Alzheimer’s disease is caused by a buildup of amyloid and tau proteins in the brain. CpG 1018 ISS may trigger an immune response to reduce amyloid protein from building up in the brain. This study has three dose levels and is for patients who have been diagnosed with either mild cognitive impairment (MCI) or mild Alzheimer’s disease dementia. CpG 1018 ISS is considered investigational because it is not Food and Drug Administration (FDA) approved for preventing AD progression.


Clinical Study Identifier: s20-00267
ClinicalTrials.gov Identifier: NCT05606341
Principal Investigator: Arjun V. Masurkar.


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