Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression (TRIADE-R33)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Major Depressive Disorder
  • Age: Between 18 Year(s) - 65 Year(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Participants must be able to give written informed consent and follow study procedures.
    2. Participants must be 18-65 years of age.
    3. Participants must have current major depressive disorder.
    4. Women of child-bearing potential must agree to use adequate contraception (e.g., oral contraceptives, intrauterine device, double barrier methods, or total abstinence from intercourse).
    5. Participants taking medications or psychotherapy approved for the treatment of major depressive disorder will need to be stable for at least 8 weeks prior to study screen.

You may not be eligible for this study if the following are true:

    1. Unwilling or unable to comply with study requirements.
    2. History of any or psychotic or bipolar disorder.
    3. Met diagnostic criteria for an alcohol or substance use disorder, post-traumatic stress disorder, obsessive-compulsive disorder, anorexia nervosa, or bulimia nervosa within the preceding 6 months.
    4. History of dementia, traumatic brain injury (TBI), or neurological disorders affecting the brain, including any history of stroke or seizure disorders requiring treatment in the last 5 years.
    5. Pregnant or nursing.
    6. Currently undergoing device-based treatment for depression or taking medications for depression other than SSRIs, SNRIs, or Wellbutrin (bupropion).
    7. Serious, unstable medical illnesses including hepatic, renal, gastroenterologic, respiratory, cardiovascular, endocrinologic, neurologic, immunologic, and hematologic disease.
    8. Any use of light-activated drugs (photodynamic therapy) within 14 days prior to study enrollment.
    9. Failure to meet standard MRI safety requirements (e.g., claustrophobia, non-removable piercings, implanted medical devices, other non-removable metals).



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