Intradialytic Myocardial Study Stunning in Maintenance Hemodialysis Patients: A Multi-Center Observational Cohort Study

Brief description of study

The purpose of this observational study is to prospectively investigate the frequency and risk factors for intradialytic myocardial stunning (IDMS--transient changes in how well the heart pumps during dialysis) in maintenance hemodialysis patients, to evaluate the prevalence of repetitive IDMS, and to investigate the role of cardiovascular autonomic control in IDMS pathophysiology using a battery of autonomic function tests (tests of the nervous system) during dialysis and on non-dialysis days.

All subjects will undergo pre- and intradialytic echocardiography during a single hemodialysis session. There will be four substudies:

  • Substudy A: a subset of participants will undergo repeat echocardiography during a 2nd session to assess the frequency of repetitive IDS
  • Substudy B: a subset of participants will undergo intradialytic testing of autonomic function during a single hemodialysis session during the baseline echocardiography scanning
  • Substudy C: a subset of participants will undergo autonomic function testing on a non-dialysis day
  • Substudy D: a subset of participants will undergo myocardial sympathetic PET scanning--a radiology test to analyze the function of the heart nervous system--in order to assess myocardial uptake of neuro-sympathetic hormones


Clinical Study Identifier: s21-01195
Principal Investigator: David Michael Charytan.


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