Intradialytic Myocardial Study Stunning in Maintenance Hemodialysis Patients: A Multi-Center Observational Cohort Study

Brief description of study

The purpose of this observational study is to prospectively investigate the frequency and risk factors for intermittent intradialyltic myocardial stunning (IDMS) in maintenance hemodialysis patients, to evaluate the prevalence of repetitive IDMS, and to investigate the role of cardiovascular autonomic control in IdMS pathophysiology using a battery of autonomic function tests during dialysis and on non-dialysis days All subjects will undergo pre- and intradialytic transthoracic echocardiography during a single hemodialysis session. There will be four substudies: • Substudy A—a subset of participants will undergo repeat scanning during a 2nd session to assess the frequency of repetitive IDS • Substudy B—a subset of participants will undergo intradialytic testing of autonomic function during a single hemodialysis session during the baseline echocardiography scanning • Substudy C—a subset of participants will undergo autonomic function testing on a non-dialysis day • Substudy D—a subset of participants will undergo myocardial sympathetic PET scanning in order to assess myocardial uptake of neuro-sympathetic hormones


Clinical Study Identifier: s21-01195
Principal Investigator: David Michael Charytan.
Other Investigators: Patricio Alejandro Millar Vernetti, Qandeel Haq Soomro, Samrachana Adhikari.


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