PERSPIRE: A pilot study of Pro-rEsolving and pRo-inflammatory reSPonses to acute exhaustIve exeRcisE in healthy individuals

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PERSPIRE: A pilot study of Pro-rEsolving and pRo-inflammatory reSPonses to acute exhaustIve exeRcisE in healthy individuals

Brief description of study

Observational, intervention study of the effects of acute, exhaustive exercise on pro-resolving and pro-inflammatory responses in healthy, trained and untrained adults. The study requires one visit (a second, optional visit may occur). At the visit, subjects will have blood drawn at several time points and also perform an exhaustive bout of treadmill exercise. Differences in specialized pro-resolving lipid mediators (SPMs) and other measures of inflammation and resolution over time will be characterized.

Clinical Study Identifier: s23-00421

ClinicalTrials.gov Identifier: NCT05923125

Principal Investigator: Sean P. Heffron.

Other Investigators: Chiara Giannarelli, Lawrence Phillips, Nathaniel Rosso Smilowitz, Jeffrey S Berger, Christopher Y. Park.

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