A pilot study of Pro-rEsolving and pRo-inflammatory reSPonses to acute exhaustIve exeRcisE in healthy individuals

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Exercise
  • Age: Between 18 Year(s) - 50 Year(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Willingness to provide informed consent and participate in PRESPIRE.
    2. Able to read and speak English adequately to provide informed consent and understand verbal and written instructions.
    3. BMI < 30kg/m2.
    4. Untrained: self-reporting no more than 1 day per week of regular exercise (inclusive of walking >5,000 steps daily and commuting via bicycle).
    5. Trained: self-reporting at least 4 hours of aerobic exercise/moderate or greater intensity physical activity weekly for the past year.

You may not be eligible for this study if the following are true:

    1. Anti-platelet medication use.
    2. Chronic inflammatory or connective tissue disease.
    3. History of bleeding or clotting disorder.
    4. Immunological deficiency.
    5. Diabetes mellitus.
    6. Stage 2 or greater hypertension on screening.
    7. Cardiovascular disease.
    8. Chronic obstructive lung disease.
    9. Active smoking.
    10. >5% body weight change over the past 6 months or plan to gain/lose weight during the study.
    11. Platelet count <100,000.
    12. Use of omega-3 fatty acid supplementation within 3 weeks of study participation.
    13. Use of drugs or supplements known to inhibit COX-1/COX-2/lipoxygenases.
    14. Corticosteroid use.
    15. Use of beta-blocker medications.
    16. Use of alpha-blocker medications.
    17. Use of NSAIDs or aspirin within 2 weeks of study participation.
    18. Vaccination within 2 weeks of study participation.
    19. Pregnancy.



If you are registered as a volunteer, please log in to contact the study team/express interest in this study.

Contact the research team to learn more about this study.

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