A pilot study of Pro-rEsolving and pRo-inflammatory reSPonses to acute exhaustIve exeRcisE in healthy individuals

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
  • Age: Between 18 Year(s) - 50 Year(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Willingness to provide informed consent and participate in PRESPIRE.
    2. Able to read and speak English adequately to provide informed consent and understand verbal and written instructions.
    3. BMI < 30kg/m2.
    4. Untrained: self-reporting no more than 1 day per week of regular exercise (inclusive of walking >5,000 steps daily and commuting via bicycle).
    5. Trained: self-reporting at least 4 hours of aerobic exercise/moderate or greater intensity physical activity weekly for the past year.

You may not be eligible for this study if the following are true:

    1. Anti-platelet medication use.
    2. Chronic inflammatory or connective tissue disease.
    3. History of bleeding or clotting disorder.
    4. Immunological deficiency.
    5. Diabetes mellitus.
    6. Stage 2 or greater hypertension on screening.
    7. Cardiovascular disease.
    8. Chronic obstructive lung disease.
    9. Active smoking.
    10. >5% body weight change over the past 6 months or plan to gain/lose weight during the study.
    11. Platelet count <100,000.
    12. Use of omega-3 fatty acid supplementation within 3 weeks of study participation.
    13. Use of drugs or supplements known to inhibit COX-1/COX-2/lipoxygenases.
    14. Corticosteroid use.
    15. Use of beta-blocker medications.
    16. Use of alpha-blocker medications.
    17. Use of NSAIDs or aspirin within 2 weeks of study participation.
    18. Vaccination within 2 weeks of study participation.
    19. Pregnancy.

If you are registered as a volunteer, please log in to contact the study team/express interest in this study.

Contact the research team to learn more about this study.

By clicking "Contact Research Team", your contact information will be sent securely to the research staff associated with the study. You will also receive a copy of this email in your inbox, as well as other notifications to determine your participation status in the study.