Using a Health Disparity Research Framework to examine mechanisms linking Obstructive Sleep Apnea with higher Alzheimer s disease risk in older Blacks/African-Americans

Brief description of study

The purpose of this study is to investigate whether older African Americans with obstructive sleep apnea (OSA) have a higher risk for Alzheimer’s Disease (AD) in comparison to older non-Hispanic Whites.

African-Americans (blacks) have twice the risk of developing AD compared to non-Hispanic whites (whites), due in part to the higher prevalence of vascular risk factors such as diabetes and hypertension. Additionally, blacks have a higher prevalence of OSA with excessive daytime sleepiness (EDS). This study aims to determine if OSA is associated with neurodegeneration and higher amounts of tau protein in the brain (a biomarker of AD) in older African Americans.




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